This article highlights medroxyprogesterone as it is used as contraception to prevent pregnancy. This activity discusses the mechanism of action, adverse effects, monitoring, and contraindications for medroxyprogesterone. Also, it highlights the important role that providers play in administering medroxyprogesterone and regularly monitoring patients for side effects.Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot.Jan 15, 2022 · itchiness. flushing (warmth and redness or deepening of color in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under ... May 15, 2002 · In fact, women frequently discontinue hormonal contraception because of irregular bleeding and other side effects. 1 – 3 One study 4 found that 32 percent of 1,657 women who started taking oral ... A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid. weakness or numbness in an arm or leg. pain in the arms, neck, back, or jaw. dizziness. faintness. If a doctor prescribes male testosterone injections to an adolescent to treat a constitutional ...Aug 1, 2023 · lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients. Rated Depo-Provera for Endometriosis Report . I was always happy and outgoing. Always with friends or making new friends to hang with. After almost 2 years on this drug I am: • Severely depressed • crazy anxiety • antisocial ( I try but I don’t ever want to be with people or do anything the more I get this shot ) • I don’t feel attracted to anyone • I cry everyday at least 5 ...Olanzapine as pamoate monohydrate is a long-acting injectable or depot form of olanzapine and provides another option for maintenance treatment of schizophrenia. As with oral olanzapine, weight gain and metabolic effects (raised serum cholesterol, triglyceride and glucose levels) are common. Establish tolerability and response to oral ...Apr 25, 2023 · When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ... The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ... A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn.Similar side effects of the pill vs. Depo-Provera injection. Both methods can cause tenderness or soreness in the breasts. Other side effects of oral contraceptives and the Depo-Provera shot include headaches and mood changes. Both methods can lead to a decreased interest in sex ( decreased libido) in some women.Methylprednisolone (brand names: Medrol®, Depo-Medrol®, A-Methapred®, Solu-Medrol®) is a glucocorticoid steroid medication used to treat many inflammatory conditions, pets with adrenal gland disease, and pets with immune-mediated diseases. It is similar to but slightly more potent than prednisone / prednisolone. In many cases, unwanted effects of the Mirena IUD are not long-term. According to Planned Parenthood, common side effects such as spotting between periods and cramping typically get better in 3 ...DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.You should talk to your healthcare provider about any possible side effects of Depo-Provera®. Most of these side effects are not common. Changes in your menstrual cycle is the most common side effect that women experience. You may experience irregular bleeding or spotting. After a year of use, about 50% of women will stop getting their periods.Methylprednisolone (Medrol) can cause changes in your fluids and electrolytes (e.g., sodium, potassium, and calcium). This can result in high blood pressure, swelling, and kidney problems. In addition, some studies suggest that methylprednisolone (Medrol) can damage the heart if used after a recent heart attack.Pros No need to take a daily pill. You’ll get a shot once every 12 to 13 weeks. Less opportunity to miss a dose. It’s very common to occasionally miss a daily pill. With a shot, you won’t have...DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.It gives long-term protection as long as you get the shot every 3 months. It's very effective. You get birth control without having to take estrogen. It can make your period lighter and...The shots may be doing more harm than good. In a new study published in the journal Radiology, researchers looked at 459 patients in a US hospital who had received one to three corticosteroid ...Long-term side effects Some diseases and medical conditions require long-term treatment with corticosteroids, at either an anti-inflammatory dose or an immunosuppressive dose. When corticosteroids will be used for more than three to four months, particularly at immunosuppressive doses, additional side effects become a concern.LO. LousArk 25 Sep 2018. Sorry to hear it's affected you so badly. The Manufacturer acknowledges that just 1 shot can make you infertile for up to 18 months, so it's clearly still having an effect in some people for many months after stopping using it.Limiting contraceptive options like DMPA may disproportionately affect adolescents and disadvantaged women. Depot medroxyprogesterone acetate inhibits the secretion of pituitary gonadotropins, resulting in anovulation and decreased production of estrogen. Decreased estrogen production is of concern because it is associated with a decrease in ...Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... Jul 15, 2023 · Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. Many negative side effects usually go away after 2-3 months, once your body gets used to the shot. You can use our birth control app to keep track of the side effects you may be having. Most people on the shot have some change in their periods, including bleeding more days than usual, spotting between periods, or no periods.altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ... Long-term effects of injection Depo-Provera (depo-medroxyprogesterone acetate) on carbohydrate and lipid metabolism were studied in 157 women who were treated continuously for a mean duration of 43.3 months. The patients were matched with 162 controls for race, age, parity and height. Glucose tolerance was impaired with higher intolerance at ... Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ...Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot.Feb 27, 2010 · SU. suzanne66 7 March 2010. Chemical castration (as it is referred to in males) by using Depo-provera lowers testosterone and reduces sex drive. Males can have sexual intercourse but do not want to. It also discourages sexual fantasies and eradicates sexual obsessions. Mood changes and depression are reported side-effects of depo-provera. Forty-three subjects (37% of discontinuers) restarted Depo-Provera during the study period, with a mean time to restart of 8.4 months after the last Depo-Provera injection. Side effects were the main reported reason for Depo-Provera discontinuation, primarily menstrual irregularities (26%) and weight gain (18%).Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... Oct 1, 2022 · Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass. Depo-Provera Vial Contraceptives. - Uses, Side Effects, This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with ... Apr 14, 2023 · For most people, being on birth control long term is safe. Birth control can lower your risk for some cancers and raise your risk for others. It can cause blood clots, heart attacks, and strokes — but the risks are small. Being on birth control doesn’t make it harder to become pregnant once you stop it. 02:48. After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding. Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ... Aug 28, 2023 · Common side effects of Depo-Estradiol may include: breast pain; headache; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding; thinning scalp hair; or. nausea, vomiting, bloating, stomach cramps. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side ... Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. Dec 15, 2010 · A prospective analysis of women using Depo-Provera found no change in sexual function after four months, and women using progestin-only pills had no difference in sexual desire compared with those ... Find patient medical information for Depo-Medrol injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... during long-term treatment ...Depo-Provera Contraceptive Injection should not be used as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate. (See Warnings and Precautions (5.1)). 1 INDICATIONS AND USAGE Depo-Provera CI is indicated only for the prevention of pregnancy. The loss of bone mineral densityWeakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Depression or other mood changes. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Flu -like signs.Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.Medical side effects: The results of two major world studies have shown that women who take Depo-Provera for two years or more before age 25 have at least a 190% increased risk of developing ...May 10, 2023 · Rated Depo-Provera for Endometriosis Report . I was always happy and outgoing. Always with friends or making new friends to hang with. After almost 2 years on this drug I am: • Severely depressed • crazy anxiety • antisocial ( I try but I don’t ever want to be with people or do anything the more I get this shot ) • I don’t feel attracted to anyone • I cry everyday at least 5 ... Potential side effects of cortisone shots increase with larger doses and repeated use. Side effects can include: Cartilage damage. Death of nearby bone. Joint infection. Nerve damage. Temporary facial flushing. Temporary flare of pain and inflammation in the joint. Temporary increase in blood sugar.One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach ...You might notice: Uneven menstrual periods or no periods at all Headaches Nervousness Depression Dizziness Acne Changes in appetite Weight gain Unwanted facial and body hair Hair loss Loss of bone mineral density Belly pain Bloating Breakthrough bleeding Fatigue Less interest in sex Weakness ... Aug 7, 2023 · signs of a blood clot - sudden numbness or weakness, severe headache, chest pain, sudden cough, coughing up blood; problems with vision or speech, swelling or pain in an arm or leg. Common Depo-Provera side effects may include: changes in your menstrual periods; weakness, feeling tired; stomach pain; feeling nervous; Sep 28, 2021 · One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images. Find patient medical information for Depo-Medrol injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... during long-term treatment ...altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ...When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot. Medical side effects: The results of two major world studies have shown that women who take Depo-Provera for two years or more before age 25 have at least a 190% increased risk of developing ...After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding. DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.Mar 6, 2013 · The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient. Contraceptive implants are a long-term birth control method. They're also called long-acting reversible contraception, or LARC. A contraceptive implant is a flexible plastic rod about the size of a matchstick that is placed under the skin of the upper arm. The implant releases a low, steady dose of the hormone progestin.PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation.Jun 16, 2021 · To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ... Potential side effects of cortisone shots increase with larger doses and repeated use. Side effects can include: Cartilage damage. Death of nearby bone. Joint infection. Nerve damage. Temporary facial flushing. Temporary flare of pain and inflammation in the joint. Temporary increase in blood sugar.Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... This article highlights medroxyprogesterone as it is used as contraception to prevent pregnancy. This activity discusses the mechanism of action, adverse effects, monitoring, and contraindications for medroxyprogesterone. Also, it highlights the important role that providers play in administering medroxyprogesterone and regularly monitoring patients for side effects.A prospective analysis of women using Depo-Provera found no change in sexual function after four months, and women using progestin-only pills had no difference in sexual desire compared with those ...To go off of this form of birth control, just don’t get your next shot. But be aware that your periods and fertility may take more than the initial three months to return. “In some people, it ...Mar 6, 2013 · The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient. Feb 22, 2022 · They might include: Abdominal pain Bloating Decreased interest in sex Depression Dizziness Headaches Irregular periods and breakthrough bleeding Nervousness Weakness and fatigue Weight gain LO. LousArk 25 Sep 2018. Sorry to hear it's affected you so badly. The Manufacturer acknowledges that just 1 shot can make you infertile for up to 18 months, so it's clearly still having an effect in some people for many months after stopping using it.weakness or numbness in an arm or leg. pain in the arms, neck, back, or jaw. dizziness. faintness. If a doctor prescribes male testosterone injections to an adolescent to treat a constitutional ...When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ...Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.Mar 3, 2023 · Similar side effects of the pill vs. Depo-Provera injection. Both methods can cause tenderness or soreness in the breasts. Other side effects of oral contraceptives and the Depo-Provera shot include headaches and mood changes. Both methods can lead to a decreased interest in sex ( decreased libido) in some women. Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach ...Depo-Provera Contraceptive Injection should not be used as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate. (See Warnings and Precautions (5.1)). 1 INDICATIONS AND USAGE Depo-Provera CI is indicated only for the prevention of pregnancy. The loss of bone mineral density altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ... May 10, 2023 · Rated Depo-Provera for Endometriosis Report . I was always happy and outgoing. Always with friends or making new friends to hang with. After almost 2 years on this drug I am: • Severely depressed • crazy anxiety • antisocial ( I try but I don’t ever want to be with people or do anything the more I get this shot ) • I don’t feel attracted to anyone • I cry everyday at least 5 ... Depo-Provera Vial Contraceptives. - Uses, Side Effects, This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with ... Common side effects of Depo-Estradiol may include: breast pain; headache; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding; thinning scalp hair; or. nausea, vomiting, bloating, stomach cramps. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side ...Risks. Abdominal pain. Bloating. Decreased interest in sex. Depression. Dizziness. Headaches. Irregular periods and breakthrough bleeding. Nervousness. Weakness and fatigue. Weight gain.
Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach .... Walk in shower with seat for elderly at lowes
Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... Aug 1, 2023 · lightening of normal skin color. pain, redness, or hard skin at the injection site. pitting or depression of the skin at the injection site. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients. Nov 24, 2017 · LousArk 24 Nov 2017. The Manufacturer recommends that you not use Depo Provera long term (more than 2 years), unless you have no option. In that case, you need to take the recommended breaks every couple of years. They state that it can take up to 18 months from the point you miss your shot, for your fertility to return. The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ... Medical side effects: The results of two major world studies have shown that women who take Depo-Provera for two years or more before age 25 have at least a 190% increased risk of developing ...Apr 14, 2023 · For most people, being on birth control long term is safe. Birth control can lower your risk for some cancers and raise your risk for others. It can cause blood clots, heart attacks, and strokes — but the risks are small. Being on birth control doesn’t make it harder to become pregnant once you stop it. 02:48. headaches and migraine. hot flashes/night sweats. nausea and vomiting. pain. vaginitis. weight gain. People taking Lupron develop symptoms that are similar to menopause, including hot flashes ...Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot. Here are a few potential side effects to be aware of if you use it. 1. You might stop having periods. The most common side effect of the shot is a change in a woman’s bleeding pattern, Jason ...Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ... The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ... Risks. Abdominal pain. Bloating. Decreased interest in sex. Depression. Dizziness. Headaches. Irregular periods and breakthrough bleeding. Nervousness. Weakness and fatigue. Weight gain.The use of Depo-Provera CI is not recommended as a long-term (i.e., longer than 2 years) birth control method unless other options are considered inadequate. BMD should be evaluated when a woman needs to continue to use Depo-Provera CI long-term. In adolescents, interpretation of BMD results should take into account patient age and skeletal ... Depo-Provera Contraceptive Injection should not be used as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate. (See Warnings and Precautions (5.1)). 1 INDICATIONS AND USAGE Depo-Provera CI is indicated only for the prevention of pregnancy. The loss of bone mineral density The birth control shot (sometimes called Depo-Provera, the Depo shot, or DMPA) contains the hormone progestin. Progestin stops you from getting pregnant by preventing ovulation. When there’s no egg in the tube, pregnancy can’t happen. It also works by making cervical mucus thicker. When the mucus on the cervix is thicker, the sperm can’t ... I got the Depo shot on Feburary 8th, 2017. The first two weeks afterwards I felt fine, surprisingly no side effects so I was happy about getting it. However, when the third week started, all hell started to break lose. Mood swings, severe depression, OCD, severe anxiety, loss of sex drive, constant spotting, loss of attraction to my BF, and ...Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... You should talk to your healthcare provider about any possible side effects of Depo-Provera®. Most of these side effects are not common. Changes in your menstrual cycle is the most common side effect that women experience. You may experience irregular bleeding or spotting. After a year of use, about 50% of women will stop getting their periods..
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